GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE280nnn/GSE280925/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE280925GEOGSEfalseZCCHC10 promotes RBM39 degradation to suppress RBM39-mediated mis-splicing in acute myeloid leukemiaOur previous studies have shown that CCHC-type zinc finger containing 10 (ZCCHC10) plays a tumor suppressive role in acute myeloid leukemia (AML) and lung cancer by activating the tumor suppressor p53. Here we report that ZCCHC10 promotes PSME3-mediated degradation of RBM39，thereby regulating transcription and mRNA splicing.2026/08/21GSE280925GSM8607571GSM8607560GSM8607570GSM8607562GSM8607573GSM8607561GSM8607572GSM8607575GSM8607564GSM8607553GSM8607574GSM8607563GSM8607566GSM8607555GSM8607554GSM8607565GSM8607576GSM8607568GSM8607557GSM8607567GSM8607556GSM8607559GSM8607569GSM860755829480280925Homo sapiens