{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE281nnn/GSE281431/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE281431"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Unraveling massive coding and non coding transcriptome dysregulation in T-PLL","description":"T-cell prolymphocytic leukemia (T-PLL) is a highly aggressive cancer affecting mature T lymphocytes, marked by a fast-progressing clinical course and resistance to standard chemotherapy. Developement of better T-PLL treatment requires identifying molecular vulnerabilities and gaining a deeper understanding of the disease’s heterogeneity. By RNA-seq profiling of T-PLL samples alongside CD4+ cells from healthy donors, we were able to document gene expression changes and pathway disruptions in malignant cells. Additionally, we discovered significant alterations in the expression of non-coding, antisense, and circular RNAs in T-PLL. This expands current knowledge on the most dysregulated genes and pathways in malignant cells and highlights in non-coding RNAs and circRNAs aberrant expression in T-PLL and in subsets carrying specific driver variants.","dates":{"publication":"2026/08/19"},"accession":"GSE281431","cross_references":{"GSM":["GSM8620692","GSM8620693","GSM8620690","GSM8620691","GSM8620696","GSM8620697","GSM8620694","GSM8620695","GSM8620700","GSM8620701","GSM8620698","GSM8620699","GSM8620704","GSM8620702","GSM8620703"],"GPL":["24676"],"GSE":["281431"],"taxon":["Homo sapiens"],"PMID":["[42588659]"]}}