GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE281nnn/GSE281431/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE281431GEOGSEfalseUnraveling massive coding and non coding transcriptome dysregulation in T-PLLT-cell prolymphocytic leukemia (T-PLL) is a highly aggressive cancer affecting mature T lymphocytes, marked by a fast-progressing clinical course and resistance to standard chemotherapy. Developement of better T-PLL treatment requires identifying molecular vulnerabilities and gaining a deeper understanding of the disease’s heterogeneity. By RNA-seq profiling of T-PLL samples alongside CD4+ cells from healthy donors, we were able to document gene expression changes and pathway disruptions in malignant cells. Additionally, we discovered significant alterations in the expression of non-coding, antisense, and circular RNAs in T-PLL. This expands current knowledge on the most dysregulated genes and pathways in malignant cells and highlights in non-coding RNAs and circRNAs aberrant expression in T-PLL and in subsets carrying specific driver variants.2026/08/19GSE281431GSM8620692GSM8620693GSM8620690GSM8620691GSM8620696GSM8620697GSM8620694GSM8620695GSM8620700GSM8620701GSM8620698GSM8620699GSM8620704GSM8620702GSM862070324676281431Homo sapiens[42588659]