GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE281nnn/GSE281481/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE281481GEOGSEfalseSingle-cell multi-omic analysis of post-transplant mesenchymal cells reveals molecular signatures and regulators of lung fibrosis (RNA-seq)Chronic lung allograft dysfunction (CLAD) is a critical challenge in lung transplantation. Dysregulated gene expression and epigenomic states in lung mesenchymal cells (MCs) play a key role in these conditions. We performed single-cell multi-omic profiling on MCs isolated from human bronchoalveolar lavage samples of lung transplant recipients with CLAD, compared with time-matched controls. Our results provide deeper insights into the transcriptomic and epigenomic changes in post-transplant MCs, nominating biomarkers and disease-associated factors with implications for future therapeutic efforts.2026/03/29GSE281481GSM8621694GSM8621693GSM8621692GSM8621691GSM8621698GSM8621697GSM8621696GSM862169534284281481Homo sapiens