{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE282nnn/GSE282281/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE282281"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Single cell RNA seq profile of Control and EPM1 patient's derived ventral brain organoids as single genotype or as mosaic at 40 days","description":"This study uses single-cell RNA sequencing (scRNA-seq) to explore the pathogenesis of progressive myoclonus epilepsy type 1 (EPM1) in cerebral organoids derived from patient cells. The analysis reveals a shift in progenitor fate toward dorsal neuron identities and a reduction in inhibitory interneurons, disrupting the excitatory/inhibitory balance and increasing electrophysiological activity.","dates":{"publication":"2026/09/01"},"accession":"GSE282281","cross_references":{"GSM":["GSM8640489","GSM8640496","GSM8640494","GSM8640495","GSM8640492","GSM8640493","GSM8640490","GSM8640491"],"GPL":["24676"],"GSE":["282281"],"taxon":["Homo sapiens"],"PMID":["[42685196]"]}}