GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE282nnn/GSE282281/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE282281GEOGSEfalseSingle cell RNA seq profile of Control and EPM1 patient's derived ventral brain organoids as single genotype or as mosaic at 40 daysThis study uses single-cell RNA sequencing (scRNA-seq) to explore the pathogenesis of progressive myoclonus epilepsy type 1 (EPM1) in cerebral organoids derived from patient cells. The analysis reveals a shift in progenitor fate toward dorsal neuron identities and a reduction in inhibitory interneurons, disrupting the excitatory/inhibitory balance and increasing electrophysiological activity.2026/09/01GSE282281GSM8640489GSM8640496GSM8640494GSM8640495GSM8640492GSM8640493GSM8640490GSM864049124676282281Homo sapiens[42685196]