{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE282nnn/GSE282870/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":[" Other","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE282870"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"microRNA-497-5p-based Screening Identifies a Novel Synthetic Lethal-type Interaction via PKMYT1 and WEE1 in Pleural Mesothelioma","description":"We discovered direct targets of miR-497-5p through biotinylated miRNA pull-down of target mRNA molecules from a epithelial subtype derived diffuse pleural mesothelioma (DPM) cell line (H2052). The pulldowns were done side by side with RNA-seq to capture the effects of miRNA on the transcriptomes of the DPM cells.","dates":{"publication":"2026/06/29"},"accession":"GSE282870","cross_references":{"GSM":["GSM8651804","GSM8651803","GSM8651805","GSM8651800","GSM8651789","GSM8651788","GSM8651799","GSM8651802","GSM8651801","GSM8651785","GSM8651796","GSM8651784","GSM8651795","GSM8651787","GSM8651798","GSM8651797","GSM8651786","GSM8651792","GSM8651791","GSM8651794","GSM8651783","GSM8651782","GSM8651793","GSM8651790"],"GPL":["20301"],"GSE":["282870"],"taxon":["Homo sapiens"],"PMID":["[40673159]"]}}