{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE282nnn/GSE282892/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE282892"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Unveiling Multi-Omics and Immune Landscapes in COVID-19 Patients' Ovaries Microenvironment for Oocyte Competency Biomarkers Identification","description":"Background: The outbreak of coronavirus disease 2019 (COVID-19) poses a considerable health threat to humanity, with potential implications for the ovarian microenvironment remaining uncertain. Methods: Transcriptomic and proteomic analyses of ovarian granulosa cells, along with metabolomic and lipidomic profiling of follicular fluid, were conducted on 17 non-COVID-19 cases and 9 COVID-19 cases. This study received approval from the ethics committee (KYLL-2022-581). Generalized estimating equations model was performed to identify oocyte competency biomarkers. Additionally, cell proliferation, apoptosis, and altered pathways were examined following lentivirus transfection. Methods: Transcriptomic and proteomic analyses of ovarian granulosa cells, along with metabolomic and lipidomic profiling of follicular fluid, were conducted on 17 non-COVID-19 cases and 9 COVID-19 cases. This study received approval from the ethics committee (KYLL-2022-581). Generalized estimating equations model was performed to identify oocyte competency biomarkers. Additionally, cell proliferation, apoptosis, and altered pathways were examined following lentivirus transfection. Conclusions: By integrating untargeted metabolomic and lipidomic features, we identified biomarkers indicative of oocyte competency influenced by COVID-19.","dates":{"publication":"2024/12/25"},"accession":"GSE282892","cross_references":{"GSM":["GSM8652309","GSM8652317","GSM8652316","GSM8652319","GSM8652318","GSM8652313","GSM8652312","GSM8652315","GSM8652314","GSM8652311","GSM8652310","GSM8652306","GSM8652328","GSM8652327","GSM8652305","GSM8652308","GSM8652307","GSM8652324","GSM8652323","GSM8652304","GSM8652326","GSM8652303","GSM8652325","GSM8652320","GSM8652322","GSM8652321"],"GPL":["24676"],"GSE":["282892"],"taxon":["Homo sapiens"]}}