{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE283nnn/GSE283000/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE283000"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Chromatin binding of nuclear transport factor Importin α in human cultured cancer cells","description":"Micronuclei (MN) are membrane-enclosed structures that contain DNA or chromatin, and their presence can lead to genomic instability. We found that importin α, a key nuclear transport factor, is highly concentrated in the MN in cultured human cancer cells. Notably, importin α is not uniformly distributed across all MN; it is localized to approximately 40% of them. This selective localization is characterized by an uncorrelated distribution relative to importin β1, CAS/CSE1L, and Ran, suggesting uncontrolled its nuclear-cytoplasmic recycling. Additionally, along with an association with euchromatin regions, we identified chromatin-regulating molecules as potential interactors with importin α and noted a significant reduction in the mobility of importin α within MN, indicating the establishment of a unique microenvironment in these importin α-enriched structures. These results indicate that importin α serves as a previously unrecognized molecular marker for assessing the quality control of MN in human cancer cells.","dates":{"publication":"2026/04/05"},"accession":"GSE283000","cross_references":{"GSM":["GSM8654480","GSM8654481","GSM8654482"],"GPL":["18460"],"GSE":["283000"],"taxon":["Homo sapiens"]}}