GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE283nnn/GSE283000/primaryOK200GenomicsHomo sapiensGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE283000GEOGSEfalseChromatin binding of nuclear transport factor Importin α in human cultured cancer cellsMicronuclei (MN) are membrane-enclosed structures that contain DNA or chromatin, and their presence can lead to genomic instability. We found that importin α, a key nuclear transport factor, is highly concentrated in the MN in cultured human cancer cells. Notably, importin α is not uniformly distributed across all MN; it is localized to approximately 40% of them. This selective localization is characterized by an uncorrelated distribution relative to importin β1, CAS/CSE1L, and Ran, suggesting uncontrolled its nuclear-cytoplasmic recycling. Additionally, along with an association with euchromatin regions, we identified chromatin-regulating molecules as potential interactors with importin α and noted a significant reduction in the mobility of importin α within MN, indicating the establishment of a unique microenvironment in these importin α-enriched structures. These results indicate that importin α serves as a previously unrecognized molecular marker for assessing the quality control of MN in human cancer cells.2026/04/05GSE283000GSM8654480GSM8654481GSM865448218460283000Homo sapiens