GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE283nnn/GSE283360/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE283360GEOGSEfalseGene expression alteration in mouse articular chondrocytes by 25-hydroxycholesterol, 25-hydroxycholesterol-3-sulfate and GW3965 treatmentPrevious studies have demonstrated that 25-hydroxycholesterol (25HC), which is involved in the initiation and progression of osteoarthritis (OA), can be sulfated by SULT2B1 to produce 25-hydroxycholesterol-3-sulfate (25HC3S). Given this background, this study aims to investigate whether 25HC3S and 25HC have different functional effects on articular chondrocytes. Additionally, since 25HC has been proven to be an endogenous ligand of liver X receptor (LXR), this study also compares the effects elicited by the LXR agonist GW3965 on articular chondrocytes to provide insights into whether 25HC and its sulfated derivative, 25HC3S, exert distinct influences on the LXR signaling pathway.2026/04/21GSE283360GSM8660785GSM8660784GSM8660794GSM8660783GSM8660782GSM8660793GSM8660789GSM8660778GSM8660777GSM8660788GSM8660776GSM8660787GSM8660786GSM8660775GSM8660792GSM8660781GSM8660791GSM8660780GSM8660790GSM866077934290283360Mus musculus