{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE284nnn/GSE284364/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE284364"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Rest-phase light disrupts hippocampal clock function and impairs object recognition memory","description":"Light exposure during the circadian rest phase is common during shift work and late-night activity, but its effects on memory remain unclear. Here, we show that 6-day rest-phase light exposure (RPL), which combines mistimed light exposure with enforced wakefulness (EW) during the circadian rest phase, impairs long-term object recognition memory but not short-delay spatial memory. Behavioral testing, single-nucleus RNA sequencing, and ex vivo electrophysiology show that RPL alters SCN clock organization and output signaling, reduces hippocampal clock-gene rhythmicity, disrupts phase-dependent synaptic gene expression in dentate gyrus and CA1 neurons, and reduces CA1 long-term potentiation. Maintaining EW without light exposure preserved object recognition memory and CA1 clock-gene expression, showing that mistimed light exposure is required for both effects in this model. Local hippocampal dexamethasone treatment also restored day–night differences in hippocampal clock-gene expression and preserved memory under RPL, supporting a role for hippocampal clock-related regulation in memory preservation. Together, these findings show that RPL alters clock-related regulation in the SCN and hippocampus and impairs object recognition memory.","dates":{"publication":"2026/08/14"},"accession":"GSE284364","cross_references":{"GSM":["GSM8682860","GSM8682861","GSM8682854","GSM8682855","GSM8682856","GSM8682857","GSM8682858","GSM8682859"],"GPL":["21273"],"GSE":["284364"],"taxon":["Mus musculus"]}}