{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE284nnn/GSE284443/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"," Homo sapiens"],"gds_type":[" Genome binding/occupancy profiling by high throughput sequencing","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE284443"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"L1CAM generates SOX2+ metastatic progenitors through planar cell polarity signaling in lung adenocarcinoma","description":"Lung adenocarcinoma (LUAD) is a leading cause of cancer-related deaths worldwide, with most fatalities attributed to metastasis. A primitive SOX2+ progenitor state, rare in primary tumors, becomes prominent in LUAD metastatic lesions and exhibits metastasis-initiating capacity. The signals that determine the emergence of SOX2+ progenitors are unknown. We report that the cell adhesion molecule L1CAM, a marker of metastasis-initiating regenerative progenitors, plays a crucial role in the emergence of LUAD SOX2+ progenitors. Mechanistically, L1CAM induces the planar cell polarity (PCP) complex to activate c-Jun, which in turn interacts with the chromodomain helicase CHD1 to drive Sox2 transcription and generate metastasis-initiating regenerative progenitors. Treatment with an L1CAM antibody drug conjugate (ADC) effectively eliminates these LUAD cells and eradicates patient-derived xenograft metastases. Our findings identify L1CAM/PCP signaling as a driver of the SOX2+ LUAD metastatic progenitor state and provide an approach to treating metastasis by targeting L1CAM+ LUAD progenitors.","dates":{"publication":"2026/04/16"},"accession":"GSE284443","cross_references":{"GSM":["GSM8684424","GSM8684423","GSM8684426","GSM8684425","GSM8684428","GSM8684427"],"GPL":["24676","24247"],"GSE":["284443"],"taxon":["Mus musculus"," Homo sapiens"]}}