{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE284nnn/GSE284500/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE284500"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptional profiling of hippocampus from a zQ175 KI mouse model of Huntington's disease treated with either HTT-10150 siRNA targeting full-length HTT or combination of HTT-634 and HTT-486 siRNAs targeting HTT1a","description":"In this study, we conducted a comprehensive transcriptional profiling of the hippocampus utilizing a zQ175 knock-in (KI) mouse model of Huntington's disease, which was treated with either HTT-10150 siRNA specifically designed to target the full-length huntingtin (Htt) mRNA or combination of HTT-634 and HTT-486 siRNAs targeting HTT1a. Our investigation aimed to assess the impact of this intervention across different time points.","dates":{"publication":"2026/05/05"},"accession":"GSE284500","cross_references":{"GSM":["GSM8685533","GSM8685412","GSM8685532","GSM8685411","GSM8685499","GSM8685535","GSM8685414","GSM8685534","GSM8685413","GSM8685537","GSM8685416","GSM8685415","GSM8685536","GSM8685418","GSM8685539","GSM8685538","GSM8685417","GSM8685492","GSM8685491","GSM8685494","GSM8685493","GSM8685496","GSM8685495","GSM8685498","GSM8685531","GSM8685410","GSM8685530","GSM8685497","GSM8685490","GSM8685409","GSM8685529","GSM8685408","GSM8685401","GSM8685489","GSM8685522","GSM8685521","GSM8685400","GSM8685488","GSM8685524","GSM8685403","GSM8685523","GSM8685402","GSM8685526","GSM8685405","GSM8685404","GSM8685525","GSM8685407","GSM8685528","GSM8685527","GSM8685406","GSM8685481","GSM8685480","GSM8685483","GSM8685482","GSM8685485","GSM8685484","GSM8685487","GSM8685520","GSM8685486","GSM8685519","GSM8685518","GSM8685478","GSM8685511","GSM8685510","GSM8685477","GSM8685513","GSM8685512","GSM8685479","GSM8685515","GSM8685514","GSM8685517","GSM8685516","GSM8685470","GSM8685472","GSM8685471","GSM8685474","GSM8685473","GSM8685476","GSM8685475","GSM8685508","GSM8685507","GSM8685509","GSM8685467","GSM8685500","GSM8685466","GSM8685469","GSM8685502","GSM8685501","GSM8685468","GSM8685504","GSM8685503","GSM8685506","GSM8685505","GSM8685461","GSM8685460","GSM8685463","GSM8685462","GSM8685465","GSM8685464","GSM8685456","GSM8685455","GSM8685576","GSM8685458","GSM8685457","GSM8685459","GSM8685450","GSM8685571","GSM8685570","GSM8685573","GSM8685452","GSM8685572","GSM8685451","GSM8685575","GSM8685454","GSM8685574","GSM8685453","GSM8685566","GSM8685445","GSM8685444","GSM8685565","GSM8685447","GSM8685568","GSM8685567","GSM8685446","GSM8685449","GSM8685569","GSM8685448","GSM8685560","GSM8685441","GSM8685562","GSM8685561","GSM8685440","GSM8685564","GSM8685443","GSM8685563","GSM8685442","GSM8685555","GSM8685434","GSM8685554","GSM8685433","GSM8685557","GSM8685436","GSM8685435","GSM8685556","GSM8685438","GSM8685559","GSM8685558","GSM8685437","GSM8685439","GSM8685393","GSM8685392","GSM8685395","GSM8685394","GSM8685551","GSM8685397","GSM8685430","GSM8685550","GSM8685396","GSM8685553","GSM8685432","GSM8685399","GSM8685398","GSM8685552","GSM8685431","GSM8685391","GSM8685390","GSM8685544","GSM8685423","GSM8685389","GSM8685543","GSM8685422","GSM8685546","GSM8685425","GSM8685424","GSM8685545","GSM8685427","GSM8685548","GSM8685547","GSM8685426","GSM8685429","GSM8685549","GSM8685428","GSM8685386","GSM8685540","GSM8685385","GSM8685421","GSM8685388","GSM8685542","GSM8685541","GSM8685387","GSM8685420","GSM8685419"],"GPL":["24247","34290"],"GSE":["284500"],"taxon":["Mus musculus"],"PMID":["[41849583]"]}}