{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE285nnn/GSE285449/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE285449"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Faecalibacterium prausnitzii induces an anti-inflammatory response and a metabolic reprogramming in human monocytes [ileum]","description":"We isolated immune cells from human intestinal lamina propria of patients with IBD and non-inflamed controls. We stimulated them with F. prausnitzii EXL01 strain, Cadaverine or lipopolysaccharide (LPS) from Escherichia coli and performed RNA-sequencing analysis. F. prausnitzii EXL01 strain induced the production of IL-10 in CD14+ monocytes from intestinal tissue of IBD patients and non-inflamed controls in a direct and dose-dependent manner, without inducing a pro-inflammatory response as compared to LPS stimulation. RNAseq analysis confirmed these results and revealed that F. prausnitzii EXL01 strain differentially affects cell energy metabolism compared to LPS. The anti-inflammatory response induced by F. prausnitzii in monocytes was dependent on mitochondrial activity. In patients with inflammatory bowel disease (IBD), increased cadaverine levels were associated with higher flare risk.","dates":{"publication":"2026/04/01"},"accession":"GSE285449","cross_references":{"GSM":["GSM8702637","GSM8702659","GSM8702638","GSM8702639","GSM8702655","GSM8702633","GSM8702634","GSM8702656","GSM8702635","GSM8702657","GSM8702658","GSM8702636","GSM8702651","GSM8702652","GSM8702630","GSM8702631","GSM8702653","GSM8702632","GSM8702654","GSM8702650","GSM8702648","GSM8702649","GSM8702627","GSM8702628","GSM8702629","GSM8702644","GSM8702645","GSM8702646","GSM8702647","GSM8702640","GSM8702641","GSM8702642","GSM8702643","GSM8702660","GSM8702661"],"GPL":["24676"],"GSE":["285449"],"taxon":["Homo sapiens"],"PMID":["[41553310]"]}}