GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE285nnn/GSE285449/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE285449GEOGSEfalseFaecalibacterium prausnitzii induces an anti-inflammatory response and a metabolic reprogramming in human monocytes [ileum]We isolated immune cells from human intestinal lamina propria of patients with IBD and non-inflamed controls. We stimulated them with F. prausnitzii EXL01 strain, Cadaverine or lipopolysaccharide (LPS) from Escherichia coli and performed RNA-sequencing analysis. F. prausnitzii EXL01 strain induced the production of IL-10 in CD14+ monocytes from intestinal tissue of IBD patients and non-inflamed controls in a direct and dose-dependent manner, without inducing a pro-inflammatory response as compared to LPS stimulation. RNAseq analysis confirmed these results and revealed that F. prausnitzii EXL01 strain differentially affects cell energy metabolism compared to LPS. The anti-inflammatory response induced by F. prausnitzii in monocytes was dependent on mitochondrial activity. In patients with inflammatory bowel disease (IBD), increased cadaverine levels were associated with higher flare risk.2026/04/01GSE285449GSM8702637GSM8702659GSM8702638GSM8702639GSM8702655GSM8702633GSM8702634GSM8702656GSM8702635GSM8702657GSM8702658GSM8702636GSM8702651GSM8702652GSM8702630GSM8702631GSM8702653GSM8702632GSM8702654GSM8702650GSM8702648GSM8702649GSM8702627GSM8702628GSM8702629GSM8702644GSM8702645GSM8702646GSM8702647GSM8702640GSM8702641GSM8702642GSM8702643GSM8702660GSM870266124676285449Homo sapiens[41553310]