{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE285nnn/GSE285838/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"," Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE285838"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Histone chaperon ASF1B recruits distinct epigenetic factors in regulation of histone variant H3.3 during the fetal and adult erythropoiesis II","description":"To gain insight into ASF1A, ASF1B and HIRA function during erythropoiesis, RNA-seq was performed in murine erythroleukemia (MEL) cells, human umbilical cord-derived progenitor erythroid 2 (HUDEP2) cells and human CD34+ erythroid progenitor cells. Notably, depletion of ASF1A, ASF1B and HIRA with/without DMSO induction significantly reduced the expression of genes associated with erythroid differentiation. Meanwhile, depletion of ASF1A and ASF1B in HUDEP2 cells as well as depletion of ASF1B in CD34+ cells significantly reduced the expression of genes associated with erythroid differentiation.","dates":{"publication":"2026/05/15"},"accession":"GSE285838","cross_references":{"GSM":["GSM8709969","GSM8709989","GSM8709988","GSM8709987","GSM8709986","GSM8709985","GSM9023800","GSM8709984","GSM8709983","GSM8709982","GSM8709981","GSM8709980","GSM9023802","GSM8709979","GSM9023801","GSM8709978","GSM8709977","GSM9023803","GSM8709976","GSM8709975","GSM8709974","GSM8709973","GSM8709972","GSM8709971","GSM8709970","GSM8709990"],"GPL":["34281","34328"],"GSE":["285838"],"taxon":["Mus musculus"," Homo sapiens"],"PMID":["[42100853]"]}}