{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE286nnn/GSE286052/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Mus musculus"," Escherichia coli"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE286052"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Massively parallel reporter assays identify functional enhancer variants at QT interval GWAS loci","description":"Our goal here is to utilize massively parallel reporter assays (MPRA) to screen for enhancer variants that can explain the observed common variants-based associations with QT interval at GWAS mapped loci. Towards this goal, we selected 1,018 bi-allelic variants that are associated with QT interval variation across 35 GWAS loci and overlap cardiac open chromatin regions, and performed MPRA-based screen in mouse cardiomyocyte HL-1 cells for variant-centered elements that act as enhancers and have significant allelic difference in their activities.","dates":{"publication":"2026/07/07"},"accession":"GSE286052","cross_references":{"GSM":["GSM8717013","GSM8717057","GSM8717058","GSM8717014","GSM8717059","GSM8717015","GSM8717016","GSM8717053","GSM8717010","GSM8717054","GSM8717055","GSM8717011","GSM8717056","GSM8717012","GSM8717050","GSM8717051","GSM8717052","GSM8717017","GSM8717018","GSM8717019","GSM8717024","GSM8717025","GSM8717026","GSM8717027","GSM8717020","GSM8717021","GSM8717022","GSM8717023","GSM8717060","GSM8717061","GSM8717062","GSM8717063","GSM8717028","GSM8717029","GSM8717035","GSM8717036","GSM8717037","GSM8717038","GSM8717031","GSM8717032","GSM8717033","GSM8717034","GSM8717030","GSM8717039","GSM8717046","GSM8717047","GSM8717048","GSM8717049","GSM8717042","GSM8717043","GSM8717044","GSM8717045","GSM8717040","GSM8717041"],"GPL":["16085","28126","21626"],"GSE":["286052"],"taxon":["Mus musculus"," Escherichia coli"]}}