{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Arabidopsis thaliana"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE286475"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"A homeobox transcription factor fine-tunes jasmonic acid biosynthesis to balance plant immunity and growth in Arabiodopsis [RNA-seq]","description":"The activation of plant immunity is typically associates with biosynthesis of defensive metabolites, such as jasmonic acid (JA) and salicylic acid (SA), to establish an effective defence response. However, constitutive activation of immunity or excessive JA production can trigger additional pathways that negatively affect plant growth. The mechanism underlying these processes, regulated by hormone signalling pathways and their crosstalk, remains elusive. In this study, we identified a homeobox transcription factor HB34 that differentially regulates jasmonic acid biosynthesis genes and growth-promoting genes to regulate such trade-off between plant immunity and growth. Under normal condition, HB34 represses the improper activation of JA-responsive genes and loss of HB34 led to excessive JA accumulation and constitutively activated JA response, which are accompanied by inhibited plant growth. Notably, overexpression of individual growth-promoting gene was sufficient to compromise the growth-inhibition. Upon pathogen infection, the transcription of HB34 is downregulated, effectively derepressing JA biosynthesis and enhancing plant disease resistance. Together, these findings reveal HB34 as a molecular switch that balance plant defense and growth by modulating JA biosynthesis and IAA signaling pathway.","dates":{"publication":"2026/06/01"},"accession":"GSE286475","cross_references":{"GSM":["GSM8728254","GSM8728253","GSM8728258","GSM8728257","GSM8728256","GSM8728255"],"GPL":["26208"],"GSE":["286475"],"taxon":["Arabidopsis thaliana"]}}