GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE287nnn/GSE287605/primary200OKTranscriptomicsMus musculus Genome binding/occupancy profiling by high throughput sequencingExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE287605GEOGSEfalseDistince macrophage subpopulations in mouse wound healingMonocytes and macrophages displaying distinctive phenotypes may be pivotal in coordinating the transition between different stages of wound healing. RNAseq results showed that day 1 macrophages segregated from day 4 and 7 macrophages, and that on days 4 and 7 macrophages segregated primarily based on F4/80-low versus F4/80-high phenotype. TNF and IL-4 pathways converge in F4/80-low macrophages at 4 days after skin wound healing, these F4/80-low macrophages express inflammatory, MHC class II and a subset of IL-4 target genes. Footprinting analysis on ATAC-seq data revealed enrichement of both NFKB1 and STAT6 in F4/80-low macrophages at 4 dp, whereas the overall differences in transcription factor binding between F4/80-high and F4/80-low macrophages diminished by 7 dpi.2026/09/02GSE287605GSM8748814GSM8748813GSM8748812GSM8748811GSM8748833GSM8748832GSM8748810GSM8748831GSM8748830GSM8748819GSM8748818GSM8748817GSM8748816GSM8748815GSM8748825GSM8748824GSM8748823GSM8748822GSM8748821GSM8748820GSM8748809GSM8748808GSM8748807GSM8748829GSM8748828GSM8748806GSM8748805GSM8748827GSM8748804GSM874882634290287605Mus musculus