{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE287nnn/GSE287831/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Non-coding RNA profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE287831"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"MicroRNA signature of lymphoblasts from amyotrophic lateral sclerosis patients as potential clinical biomarkers","description":"MicroRNAs (miRNAs) are small, non-coding RNAs involved in different cellular functions that have emerged as key regulators of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). ALS is a fatal disease that lacks of not only effective treatments, but also presents delays in its diagnosis, since useful clinical biomarkers are unavailable. In recent years, high-throughput sequencing strategies have appeared to find new ALS biomarkers, to improve early diagnosis and to assess the efficacy of new treatments. Since immortalized lymphocytes obtained from peripheral blood are a suitable model to study pathological features of ALS, we use these samples with the aim of characterize the miRNAs dysregulated in ALS patients. Next-generation sequencing (NGS) was utilized in order to analyse miRNAs expression profiles in immortalized lymphocytes from healthy controls, sporadic ALS (sALS) and familial ALS with mutations in superoxide dismutase 1 (SOD1-ALS). The screening analysis of the NGS data identified a set of dysregulated miRNAs, of which we chose 9 candidates for qRT-PCR validation, identifying for the first time the possible importance of hsa-miR-6821-5p as ALS biomarker.","dates":{"publication":"2026/06/16"},"accession":"GSE287831","cross_references":{"GSM":["GSM8752120","GSM8752121","GSM8752113","GSM8752124","GSM8752125","GSM8752114","GSM8752122","GSM8752123","GSM8752117","GSM8752118","GSM8752126","GSM8752115","GSM8752116","GSM8752127","GSM8752119"],"GPL":["18573"],"GSE":["287831"],"taxon":["Homo sapiens"]}}