GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE287nnn/GSE287900/primary200OKTranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE287900GEOGSEfalseEndometrial mesenchymal stem cell derived exosomal miR-4669 promotes EMT by inducing M2 macrophage polarization via the DUSP6/ERK pathway in adenomyosisAdenomyosis-associated macrophage (AAM) polarization-induced epithelial‐mesenchymal transition (EMT) has been implicated as a key driver in AM progression. Mechanistic studies revealed that miR-4669 induces M2 macrophage polarization by directly downregulating DUSP6 expression and activating the MAPK/ERK pathway. In turn, the polarized M2 macrophages promote EMT in ISK cells via TGF-β1 secretion. In vivo studies demonstrated that miR-4669 depletion inhibits EECs invasion and migration by targeting the DUSP6/ERK1/2 pathway in macrophages.2026/06/30GSE287900GSM8754187GSM8754186GSM8754185GSM8754184GSM8754183GSM875418234284287900Homo sapiens