GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE287nnn/GSE287988/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE287988GEOGSEfalseIdentified gene changes through RNA-sequencing following the knockdown of the COP1 gene in liver cancerCOP1 is a ubiquitin E3 ligase that degrades the cancer suppressor gene p53. COP1 is overexpressed in human hepatocellular carcinoma, and there is evidence that knocking down COP1 can inhibit the growth of liver cancer. We hypothesized that COP1 may also be involved in the metabolism of liver cancer. To explore this, we treated human liver cancer cell lines Huh7 and HepG2 with COP1-siRNA and conducted RNA sequencing.2026/04/15GSE287988GSM8756870GSM8756867GSM8756868GSM875686924676287988Homo sapiens[41940593]