{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE288nnn/GSE288621/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE288621"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Comparative Single Cell RNA Sequencing of Notch2 and RBPJ-deficient mononuclear phagocyte cells from the spleen","description":"Splenic mononuclear phagocytes are critical in various homeostatic processes as well as immune responses. We employed single-cell RNA sequencing to investigate mononuclear phagocytic cell subsets, including splenic red pulp macrophages, monocytes, and dendritic cells in the spleen, with a focus on how Notch2 and its nuclear mediator Rbpj regulate these subsets. Our study offers a comparative analysis of splenic mononuclear phagocytes and specifically red pulp macrophages examining phagocytes isolated from myeloid Notch2 (N2ΔCx3cr1)-, and Rbpj (RbpjΔCx3cr1)-deficient mice or control animals. Our findings may provide further insights into the heterogeneity and development of the splenic mononuclear phagocytic system including splenic macrophages and monocytes.","dates":{"publication":"2026/08/18"},"accession":"GSE288621","cross_references":{"GSM":["GSM8771408","GSM8771407"],"GPL":["19057"],"GSE":["288621"],"taxon":["Mus musculus"]}}