{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE288nnn/GSE288748/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE288748"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"The liver clock drives circadian rhythms in white adipose tissue [AML12]","description":"Circadian rhythms are integral to maintaining metabolic health by temporally coordinating metabolic functions across tissues. However, the mechanisms underlying circadian cross-tissue coordination remain poorly understood. In this study, we uncover a central role for the liver clock in regulating circadian rhythms in white adipose tissue (WAT). Using a liver-specific Bmal1 knockout mouse model, we show that hepatic circadian control is crucial for lipid metabolism in WAT. In addition, by utilizing a model where functional clocks are restricted to the liver, we demonstrate that the liver clock alone drives circadian gene expression in WAT, including Cebpa, a key regulator of adipogenesis. Mechanistically, we show that circadian liver-to-WAT communication is mediated through secreted proteins, including the adaptor protein 14-3-3η (Ywhah). The clinical relevance of these findings is supported by human cohort data, which correlate liver YWHAH expression with lipid metabolic pathways in WAT and cardiometabolic risk factors. These findings provide a mechanistic framework for how the liver clock coordinates WAT physiology and highlights its central role in cardiometabolic health, offering potential insights for targeted circadian-based therapies for metabolic disorders.","dates":{"publication":"2025/02/11"},"accession":"GSE288748","cross_references":{"GSM":["GSM8774549","GSM8774548","GSM8774547","GSM8774569","GSM8774546","GSM8774568","GSM8774567","GSM8774545","GSM8774544","GSM8774566","GSM8774543","GSM8774565","GSM8774564","GSM8774542","GSM8774541","GSM8774563","GSM8774584","GSM8774540","GSM8774562","GSM8774561","GSM8774583","GSM8774560","GSM8774582","GSM8774581","GSM8774580","GSM8774539","GSM8774538","GSM8774537","GSM8774559","GSM8774558","GSM8774557","GSM8774579","GSM8774578","GSM8774556","GSM8774555","GSM8774577","GSM8774554","GSM8774576","GSM8774553","GSM8774575","GSM8774552","GSM8774574","GSM8774573","GSM8774551","GSM8774550","GSM8774572","GSM8774571","GSM8774570"],"GPL":["24247"],"GSE":["288748"],"taxon":["Mus musculus"]}}