{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE289nnn/GSE289680/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE289680"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Oxytocin is required for normal milk fat production","description":"We used single-nucleus RNA-seq to examine the heterogeneity of lactating mammary glands (MGs) and the transcriptional profiles of mammary epithelial cells (MECs) in control and adipocyte-specific oxytocin receptor knockout (OxtrΔAd) mice. Our analysis identified all expected MG cell types, including MECs, myoepithelial cells, adipocytes, adipose progenitors, hormone-sensing progenitors, vascular, and immune cells. Notably, OxtrΔAd MGs exhibited a profound metabolic shift in MECs, characterized by reduced mTOR signaling, increased autophagy, and decreased lipid synthesis. These findings underscore the essential role of OXT-driven adipose lipolysis in supporting lactation.","dates":{"publication":"2026/06/08"},"accession":"GSE289680","cross_references":{"GSM":["GSM8796392","GSM8796393"],"GPL":["24247"],"GSE":["289680"],"taxon":["Mus musculus"]}}