{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE289731"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Effect of overexpression of Lipoprotein lipase (LPL) on MS-1 endothelial cells","description":"Immune regulation of endothelial cell is esstential for efficient anti-tumor T cell immunity.We here report LPL lipoprotein lipase as a key regulator of endothelial immune response. The overexpression of LPL results in enhanced antigen presentation on endothelial cell, which in turns enhance T cell homing.Moreover, LPL also enhance the sensitivity of EC to IFN-g exposure, with elevated percentage of apoptotic cells. Taken together, our data provide a molecular framework of the effect of LPL on endothelial cells.","dates":{"publication":"2026/05/20"},"accession":"GSE289731","cross_references":{"GSM":["GSM8797659","GSM8797656","GSM8797655","GSM8797658","GSM8797657","GSM8797654","GSM8797660"],"GPL":["21626"],"GSE":["289731"],"taxon":["Mus musculus"]}}