{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE289nnn/GSE289830/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE289830"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptional regulation of IRF3, MEF2A, and MEF2C by cGAS-STING activation in mouse microglia","description":"We examined whether cGAS-STING activation inhibits Mef2 binding to Aβ clearance genes and whether H-151 reverses this effect. Mef2a and Mef2c, the most expressed Mef2 members in microglia, showed reduced binding upon diABZI-induced cGAS-STING activation, coinciding with increased Irf3 binding and downstream gene expression. H-151 restored Mef2 binding at enhancers of Aβ phagocytosis-related genes, including Itgax and Trem2. These findings link cGAS-STING activation to Mef2 inhibition and impaired Aβ clearance, reversible through STING inhibition.","dates":{"publication":"2026/10/01"},"accession":"GSE289830","cross_references":{"GSM":["GSM8799916","GSM8799927","GSM8799928","GSM8799917","GSM8799936","GSM8799925","GSM8799914","GSM8799915","GSM8799926","GSM8799937","GSM8799923","GSM8799934","GSM8799924","GSM8799935","GSM8799921","GSM8799932","GSM8799933","GSM8799922","GSM8799930","GSM8799931","GSM8799920","GSM8799918","GSM8799929","GSM8799919"],"GPL":["30172"],"GSE":["289830"],"taxon":["Mus musculus"]}}