GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE289nnn/GSE289830/primaryOK200GenomicsMus musculusGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE289830GEOGSEfalseTranscriptional regulation of IRF3, MEF2A, and MEF2C by cGAS-STING activation in mouse microgliaWe examined whether cGAS-STING activation inhibits Mef2 binding to Aβ clearance genes and whether H-151 reverses this effect. Mef2a and Mef2c, the most expressed Mef2 members in microglia, showed reduced binding upon diABZI-induced cGAS-STING activation, coinciding with increased Irf3 binding and downstream gene expression. H-151 restored Mef2 binding at enhancers of Aβ phagocytosis-related genes, including Itgax and Trem2. These findings link cGAS-STING activation to Mef2 inhibition and impaired Aβ clearance, reversible through STING inhibition.2026/10/01GSE289830GSM8799916GSM8799927GSM8799928GSM8799917GSM8799936GSM8799925GSM8799914GSM8799915GSM8799926GSM8799937GSM8799923GSM8799934GSM8799924GSM8799935GSM8799921GSM8799932GSM8799933GSM8799922GSM8799930GSM8799931GSM8799920GSM8799918GSM8799929GSM879991930172289830Mus musculus