{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE290nnn/GSE290136/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Methylation profiling"],"species":["Homo sapiens"],"gds_type":["Methylation profiling by array"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE290136"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Methylation profiling of BRAF-altered pediatric low-grade gliomas","description":"Gliomas are a major cause of cancer-related death in adolescents and young adults (AYA, ages 15-39 years). Different molecular alterations drive gliomas in children and adults leading to distinct biology and clinical consequences. At the convergence of these age groups - the AYA population – little is known about the implications of pediatric vs adult-type alterations. To address this, we analyzed a population-based cohort of 1456 clinically and molecularly characterized gliomas aged 0-39 years. Potentially targetable pediatric-type alterations were found in 31% of AYA gliomas and conferred superior outcomes compared to adult-type alterations (p<0.01). AYA low-grade gliomas with specific RAS/MAPK alterations exhibited senescent phenotype, tended to arise in different locations and were associated with superior outcome compared with children, suggesting different cellular origins. IDH mutations, BRAF p.V600E and FGFR alterations were associated with risk of malignant transformation for hemispheric tumors with worse outcome with increased age. These observations have significant implications for understanding gliomagenesis. These insights may provide rationale for earlier intervention for certain tumors to disrupt the typical behavior, leading to improved outcome.","dates":{"publication":"2026/02/19"},"accession":"GSE290136","cross_references":{"GSM":["GSM8806768","GSM8806724","GSM8806725","GSM8806769","GSM8806722","GSM8806766","GSM8806723","GSM8806767","GSM8806728","GSM8806729","GSM8806726","GSM8806727","GSM8806760","GSM8806761","GSM8806720","GSM8806764","GSM8806765","GSM8806721","GSM8806762","GSM8806763","GSM8806757","GSM8806713","GSM8806714","GSM8806758","GSM8806711","GSM8806755","GSM8806756","GSM8806712","GSM8806717","GSM8806718","GSM8806759","GSM8806715","GSM8806716","GSM8806719","GSM8806750","GSM8806753","GSM8806754","GSM8806710","GSM8806751","GSM8806752","GSM8806746","GSM8806747","GSM8806703","GSM8806788","GSM8806744","GSM8806745","GSM8806789","GSM8806706","GSM8806707","GSM8806748","GSM8806704","GSM8806705","GSM8806749","GSM8806708","GSM8806709","GSM8806782","GSM8806783","GSM8806780","GSM8806781","GSM8806742","GSM8806786","GSM8806743","GSM8806787","GSM8806740","GSM8806784","GSM8806785","GSM8806741","GSM8806779","GSM8806735","GSM8806736","GSM8806777","GSM8806733","GSM8806734","GSM8806778","GSM8806739","GSM8806737","GSM8806738","GSM8806771","GSM8806772","GSM8806770","GSM8806731","GSM8806775","GSM8806776","GSM8806732","GSM8806773","GSM8806774","GSM8806730"],"GPL":["21145"],"GSE":["290136"],"taxon":["Homo sapiens"]}}