{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE290nnn/GSE290257/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE290257"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptional rewiring by enhancer methylation in CBFA2T3-GLIS2–driven pediatric acute megakaryoblastic leukemia","description":"Chemotherapy resistance and relapse remain major challenges in pediatric acute myeloid leukemia (pAML), particularly in acute megakaryoblastic leukemia (AMKL) driven by the CBFA2T3-GLIS2 (C/G) fusion. To investigate the epigenetic mechanisms contributing to these challenges, we employed multi-epigenomic approaches to identify oncogenic enhancers at cis-regulatory elements (CREs) that drive aberrant gene expression.","dates":{"publication":"2026/07/13"},"accession":"GSE290257","cross_references":{"GSM":["GSM8809383","GSM8809372","GSM8809373","GSM8809384","GSM8809374","GSM8809375","GSM8809380","GSM8809370","GSM8809381","GSM8809382","GSM8809371","GSM8809376","GSM8809377","GSM8809378","GSM8809379"],"GPL":["24676"],"GSE":["290257"],"taxon":["Homo sapiens"],"PMID":["[41141393]"]}}