GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE290nnn/GSE290308/primaryOK200TranscriptomicsHomo sapiens Non-coding RNA profiling by high throughput sequencingExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE290308GEOGSEfalseDegradation of AGO2 by TRIM25 drives cancer progression and chemotherapy resistanceAGO2, as a key member of the RISC complex, is underexpressed in a variety of tumor cells. It is shown that the E3 ligase TRIM25 is highly expressed in a variety of tumor cells and mediates the degradation of the ubiquitin-proteasome pathway of AGO2. This effect of TRIM25 on AGO2 promotes tumor progression and resistance of tumor cells to chemotherapeutic agents. The specific mechanism is that TRIM25 regulates the level of miR-148b-5p in cells through AGO2, and then regulates the downstream ABCC1. Based on the above results, targeting miR-148b-5p provides a new strategy for the treatment of tumors.2026/04/25GSE290308GSM8810240GSM8810241GSM8810239GSM8810237GSM8810248GSM8810238GSM8810246GSM8810247GSM8810244GSM8810245GSM8810242GSM88102432030124676290308Homo sapiens