{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE290nnn/GSE290409/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Methylation profiling"],"species":["Homo sapiens"],"gds_type":["Methylation profiling by high throughput sequencing"," Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE290409"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Maternal pre-conceptional underweight induces fetal growth restriction via placental DNA methylation alterations","description":"An increasing number of individuals are striving for ideal body figures, and reproductive-aged females with a body mass index (BMI) less than 18.5kg/m2 account for a significant proportion. However, the effects of maternal pre-conceptional underweight on fetal growth remain poorly explored. Epigenetic modifications are crucial in regulating the expression of development-related genes in the placenta. This study aims to investigate the impact of maternal pre-conceptional underweight on fetal growth and the associated epigenetic mechanisms in the placenta.In conclusion, our findings illustrated that DNA methylation abnormality of the energy-related genes in the placenta represented a key mechanism between maternal pre-gestational exposure to underweight and fetal development, highlighting the importance of pre-conceptional interventions in reducing the effects of maternal unhealthy exposure on offspring health.","dates":{"publication":"2026/05/06"},"accession":"GSE290409","cross_references":{"GSM":["GSM8812259","GSM8812269","GSM8812258","GSM8812268","GSM8812257","GSM8812267","GSM8812256","GSM8812255","GSM8812266","GSM8812265","GSM8812254","GSM8812264","GSM8812253","GSM8812263","GSM8812262","GSM8812261","GSM8812260","GSM8812270"],"GPL":["24676","29480"],"GSE":["290409"],"taxon":["Homo sapiens"],"PMID":["[41826896]"]}}