GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE290nnn/GSE290409/primaryOK200Methylation profilingHomo sapiensMethylation profiling by high throughput sequencing Expression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE290409GEOGSEfalseMaternal pre-conceptional underweight induces fetal growth restriction via placental DNA methylation alterationsAn increasing number of individuals are striving for ideal body figures, and reproductive-aged females with a body mass index (BMI) less than 18.5kg/m2 account for a significant proportion. However, the effects of maternal pre-conceptional underweight on fetal growth remain poorly explored. Epigenetic modifications are crucial in regulating the expression of development-related genes in the placenta. This study aims to investigate the impact of maternal pre-conceptional underweight on fetal growth and the associated epigenetic mechanisms in the placenta.In conclusion, our findings illustrated that DNA methylation abnormality of the energy-related genes in the placenta represented a key mechanism between maternal pre-gestational exposure to underweight and fetal development, highlighting the importance of pre-conceptional interventions in reducing the effects of maternal unhealthy exposure on offspring health.2026/05/06GSE290409GSM8812259GSM8812269GSM8812258GSM8812268GSM8812257GSM8812267GSM8812256GSM8812255GSM8812266GSM8812265GSM8812254GSM8812264GSM8812253GSM8812263GSM8812262GSM8812261GSM8812260GSM88122702467629480290409Homo sapiens[41826896]