{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE290nnn/GSE290458/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE290458"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"IFN-γ induction of GBP1 drives aberrant macrophage activation in human skin granulomas","description":"Granuloma annulare (GA) and cutaneous sarcoidosis (cSAR), non-communicable skin conditions, possess an overlapping immunopathology, in which the aberrant activation of macrophages by IFN-γ constitutes a central driver of disease. Nevertheless, our understanding of the molecular events occurring in pathologically activated GA and cSAR macrophages remains limited. Here, we analyzed published single-cell RNA sequencing data of GA and cSAR and performed in-vitro experiments with primary human cells, allowing us to show that oxidative phosphorylation (OXPHOS) is a dominant metabolic pathway in IFN-γ-activated macrophages. Furthermore, we identify an IFN-γ-induced, OXPHOS-sensitive response network in human GA and cSAR macrophages. Within this network, GBP1 plays a central role in controlling IFN-γ-mediated macrophage activation. Meanwhile, inhibition of OXPHOS and GBP1 both promoted resolution of granulomas and prevented granuloma induction in a human in-vitro granuloma model. Taken together, our study suggests that OXPHOS and GBP1 represent therapeutic strategies for treating cutaneous granulomatous diseases.","dates":{"publication":"2026/04/18"},"accession":"GSE290458","cross_references":{"GSM":["GSM8814870","GSM8814871","GSM8814850","GSM8814851","GSM8814830","GSM8814852","GSM8814853","GSM8814831","GSM8814854","GSM8814832","GSM8814833","GSM8814855","GSM8814856","GSM8814834","GSM8814857","GSM8814835","GSM8814836","GSM8814858","GSM8814859","GSM8814837","GSM8814838","GSM8814839","GSM8814860","GSM8814861","GSM8814862","GSM8814840","GSM8814863","GSM8814841","GSM8814842","GSM8814864","GSM8814865","GSM8814843","GSM8814866","GSM8814844","GSM8814845","GSM8814867","GSM8814868","GSM8814846","GSM8814847","GSM8814825","GSM8814869","GSM8814848","GSM8814826","GSM8814827","GSM8814849","GSM8814828","GSM8814829"],"GPL":["21290"],"GSE":["290458"],"taxon":["Homo sapiens"]}}