{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE291nnn/GSE291144/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE291144"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic profiling of cells treated with a novel CDK12/13 inhibitor, CTX-439","description":"We developed a novel clinical-grade CDK12/13 inhibitor, CTX-439, and analyzed transcriptomic changes upon CTX-439 treatment. CTX-439 downregulated a large number of genes including DDR genes. By analyzing rRNA-depleted nuclear RNA, CTX-439 caused a defect in 3' end processing, showing an increased readthrough transcription. This caused rapid MCL1 downregulation, which can be combined with BCL-xL inhibition to induce apoptosis.","dates":{"publication":"2026/09/14"},"accession":"GSE291144","cross_references":{"GSM":["GSM8829723","GSM8829712","GSM8829724","GSM8829713","GSM8829725","GSM8829714","GSM8829726","GSM8829715","GSM8829716","GSM8829706","GSM8829717","GSM8829718","GSM8829707","GSM8829719","GSM8829708","GSM8829709","GSM8829720","GSM8829721","GSM8829710","GSM8829722","GSM8829711"],"GPL":["28038"],"GSE":["291144"],"taxon":["Homo sapiens"]}}