GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE291nnn/GSE291144/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE291144GEOGSEfalseTranscriptomic profiling of cells treated with a novel CDK12/13 inhibitor, CTX-439We developed a novel clinical-grade CDK12/13 inhibitor, CTX-439, and analyzed transcriptomic changes upon CTX-439 treatment. CTX-439 downregulated a large number of genes including DDR genes. By analyzing rRNA-depleted nuclear RNA, CTX-439 caused a defect in 3' end processing, showing an increased readthrough transcription. This caused rapid MCL1 downregulation, which can be combined with BCL-xL inhibition to induce apoptosis.2026/09/14GSE291144GSM8829723GSM8829712GSM8829724GSM8829713GSM8829725GSM8829714GSM8829726GSM8829715GSM8829716GSM8829706GSM8829717GSM8829718GSM8829707GSM8829719GSM8829708GSM8829709GSM8829720GSM8829721GSM8829710GSM8829722GSM882971128038291144Homo sapiens