GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE291nnn/GSE291267/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE291267GEOGSEfalseDUX4.6 siRNA in vitro activity in FSHD patient-derived myotubesFacioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant muscular disease caused by the aberrant ectopic expression of DUX4 in skeletal muscle. There are no approved therapies for FSHD to date, and strategies aimed at reducing DUX4 expression in skeletal muscle of FSHD patients are promising therapeutic approaches. Here we demonstrate DUX4.6 siRNA activity in reducing DUX4-regulated gene expression in FSHD patient-derived myotubes in vitro.2026/03/08GSE291267GSM8832377GSM8832355GSM8832376GSM8832354GSM8832375GSM8832353GSM8832374GSM8832359GSM8832358GSM8832379GSM8832357GSM8832356GSM8832378GSM8832373GSM8832372GSM8832371GSM8832370GSM8832366GSM8832365GSM8832364GSM8832363GSM8832369GSM8832368GSM8832367GSM8832380GSM8832362GSM8832384GSM8832383GSM8832361GSM8832382GSM8832360GSM883238124676291267Homo sapiens