{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE291337"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Hijacking innate immunity to enhance mRNA therapeutics","description":"The therapeutic success of in vitro-transcribed (IVT) mRNA depends on its stability and efficient translation. However, IVT mRNA is highly susceptible to immune-mediated degradation, limiting its efficacy. Here, we co-transfected IVT mCherry mRNA with immune suppressor M or SOCS1 mRNA in human umbilical vein endothelial cells (HUVECs) for 6h and 24h to explore whether hijacking innate immunity could enhance expression and half-life of IVT mRNA. Subsequently, RNA-seq was performed to investigate the transcriptomic changes in HUVECs after transfecting IVT mRNA. We sought to clarify the potential mechanism underlying degradation of IVT mRNA.","dates":{"publication":"2026/03/25"},"accession":"GSE291337","cross_references":{"GSM":["GSM8833649","GSM8833648","GSM8833647","GSM8833642","GSM8833663","GSM8833641","GSM8833640","GSM8833662","GSM8833661","GSM8833646","GSM8833645","GSM8833644","GSM8833643","GSM8833660","GSM8833639","GSM8833638","GSM8833637","GSM8833659","GSM8833658","GSM8833653","GSM8833652","GSM8833651","GSM8833650","GSM8833657","GSM8833656","GSM8833655","GSM8833654"],"GPL":["24676"],"GSE":["291337"],"taxon":["Homo sapiens"]}}