GEOTranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE291337GEOGSEfalseHijacking innate immunity to enhance mRNA therapeuticsThe therapeutic success of in vitro-transcribed (IVT) mRNA depends on its stability and efficient translation. However, IVT mRNA is highly susceptible to immune-mediated degradation, limiting its efficacy. Here, we co-transfected IVT mCherry mRNA with immune suppressor M or SOCS1 mRNA in human umbilical vein endothelial cells (HUVECs) for 6h and 24h to explore whether hijacking innate immunity could enhance expression and half-life of IVT mRNA. Subsequently, RNA-seq was performed to investigate the transcriptomic changes in HUVECs after transfecting IVT mRNA. We sought to clarify the potential mechanism underlying degradation of IVT mRNA.2026/03/25GSE291337GSM8833649GSM8833648GSM8833647GSM8833642GSM8833663GSM8833641GSM8833640GSM8833662GSM8833661GSM8833646GSM8833645GSM8833644GSM8833643GSM8833660GSM8833639GSM8833638GSM8833637GSM8833659GSM8833658GSM8833653GSM8833652GSM8833651GSM8833650GSM8833657GSM8833656GSM8833655GSM883365424676291337Homo sapiens