{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE291nnn/GSE291600/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE291600"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Complement C3aR deletion does not attenuate neurodegeneration in a tauopathy model or alter acute inflammation-induced gene expression changes in the brain","description":"C3aR is highly expressed in microglia in the mouse brain and has been shown to play a role in neuroinflammation. This study examines single cell RNA expression profiles and cellularity changes in mouse hippocampi from WT or C3aRKO mice injected with PBS or LPS. The results from this study potentially provides a useful ScRNAseq dataset for LPS induced effects, critical insights for future C3aR inhibition efficacy readouts.","dates":{"publication":"2026/03/23"},"accession":"GSE291600","cross_references":{"GSM":["GSM8838259","GSM8838268","GSM8838257","GSM8838269","GSM8838258","GSM8838266","GSM8838267","GSM8838256","GSM8838275","GSM8838264","GSM8838265","GSM8838262","GSM8838273","GSM8838274","GSM8838263","GSM8838271","GSM8838260","GSM8838261","GSM8838272","GSM8838270"],"GPL":["21103"],"GSE":["291600"],"taxon":["Mus musculus"]}}