{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE291nnn/GSE291703/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by array"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE291703"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Expression data from 16HBE14o- cells","description":"E-liquid flavorings are one of the driving attractors for young electronic cigarette users. The added flavors are considered safe for oral ingestion, however long-term respiratory effects remain unknown and unassessed. This study aimed to systematically investigate the intrinsic toxicity of individual flavors in a submerged lung cell model and in aerosolized form having a more complex composition using an air-liquid interface (ALI) lung cell model. 16HBE14o- bronchial epithelial cells were exposed in submerged condition for 24 h to non-cytotoxic doses of cinnamaldehyde, eugenol, vanillin and diacetyl. Cells were exposed at ALI to aerosols of self-made e-liquids containing 70 µg mL-1 cinnamaldehyde, eugenol, or vanillin for 10 min with 24 h post-exposure. Transcriptomic changes were analyzed using the Clariom™ S assay in order to understand mechanistic toxicity due to flavoring exposure.","dates":{"publication":"2026/09/30"},"accession":"GSE291703","cross_references":{"GSM":["GSM8840380","GSM8840381","GSM8840401","GSM8840402","GSM8840403","GSM8840404","GSM8840405","GSM8840406","GSM8840407","GSM8840408","GSM8840382","GSM8840383","GSM8840384","GSM8840385","GSM8840386","GSM8840387","GSM8840388","GSM8840400","GSM8840389","GSM8840390","GSM8840391","GSM8840392","GSM8840409","GSM8840379","GSM8840412","GSM8840393","GSM8840394","GSM8840395","GSM8840396","GSM8840397","GSM8840398","GSM8840410","GSM8840399","GSM8840377","GSM8840411","GSM8840378"],"GPL":["23159"],"GSE":["291703"],"taxon":["Homo sapiens"]}}