{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE291nnn/GSE291967/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Homo sapiens"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE291967"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Chromatin does not fully acquire the properties of post-mortem neurons during iPSCs-to-neurons differentiation.","description":"Induced pluripotent stem cells (iPSCs) have fundamentally advanced the field of neuroscience, offering a highly adaptable methodology for generating patient-specific neurons and modeling neurological diseases. However, a critical question remains: how accurately do iPSC-derived neurons mimic the molecular and structural intricacies of post-mortem neurons? In this study, we embark on a comprehensive investigation of chromatin architecture in both iPSC-derived and post-mortem neurons. We collected and uniformly processed the largest collection of publicly available Hi-C datasets for human and mouse neurons, along with our newly generated maps. The thorough analysis on the resulting data reveals that iPSC-derived neurons retain properties of non-differentiated cells and resemble developing stages of neurons rather than fully mature neurons. Our study not only provides a detailed comparison of chromatin architecture between iPSC-derived and post-mortem neurons but also offers the largest dataset of uniformly processed Hi-C data for human and mouse neurons.","dates":{"publication":"2026/06/17"},"accession":"GSE291967","cross_references":{"GSM":["GSM8845859","GSM8845858","GSM8845862","GSM8845863","GSM8845860","GSM8845861"],"GPL":["20301"],"GSE":["291967"],"taxon":["Homo sapiens"]}}