{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE292nnn/GSE292558/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE292558"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic Analysis of WT and IGF2BP2 KO Macrophages Reveals Metabolic Alterations","description":"This dataset contains RNA-Seq data from wild-type (WT) and IGF2BP2 knockout (KO) bone marrow-derived macrophages (BMMs) under basal and IL-4-stimulated conditions. Loss of IGF2BP2 led to significant transcriptional changes, particularly in genes regulating metabolism, mitochondrial function, and cell migration. Pathway analysis revealed a metabolic shift toward glycolysis and reduced migratory capacity. Details: Int J Biol Sci 2026; 22(6):2754-2773. doi:10.7150/ijbs.122142","dates":{"publication":"2026/03/01"},"accession":"GSE292558","cross_references":{"GSM":["GSM8861421","GSM8861410","GSM8861420","GSM8861419","GSM8861416","GSM8861415","GSM8861418","GSM8861417","GSM8861412","GSM8861411","GSM8861414","GSM8861413"],"GPL":["19057"],"GSE":["292558"],"taxon":["Mus musculus"],"PMID":["[41943844]"],"DOI":["10.7150/ijbs.122142"]}}