{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE292nnn/GSE292601/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE292601"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Epithelial interferon-stimulated gene programs modulate chemotherapy sensitivity in colorectal cancer via EPSTI1","description":"Precision oncology research typically utilizes patient-derived tumor organoids (PDTO) to predict clinical outcomes, but such efforts are often not directed towards identification of molecular factors underlying differential responses to therapy. Here, we performed bulk RNA-sequencing on treatment-naive PDTOs and combined gene expression data with in vitro drug response data to identify transcriptomic features and programs associated with low chemosensitivity.","dates":{"publication":"2026/06/30"},"accession":"GSE292601","cross_references":{"GSM":["GSM8862271","GSM8862270","GSM8862277","GSM8862310","GSM8862276","GSM8862312","GSM8862279","GSM8862278","GSM8862311","GSM8862273","GSM8862272","GSM8862275","GSM8862274","GSM8862318","GSM8862317","GSM8862319","GSM8862314","GSM8862313","GSM8862316","GSM8862315","GSM8862280","GSM8862282","GSM8862281","GSM8862321","GSM8862288","GSM8862320","GSM8862287","GSM8862323","GSM8862289","GSM8862322","GSM8862284","GSM8862283","GSM8862286","GSM8862285","GSM8862329","GSM8862328","GSM8862325","GSM8862324","GSM8862327","GSM8862326","GSM8862291","GSM8862290","GSM8862293","GSM8862292","GSM8862299","GSM8862298","GSM8862295","GSM8862294","GSM8862297","GSM8862330","GSM8862296","GSM8862301","GSM8862300","GSM8862307","GSM8862306","GSM8862309","GSM8862308","GSM8862303","GSM8862269","GSM8862302","GSM8862305","GSM8862304"],"GPL":["24676"],"GSE":["292601"],"taxon":["Homo sapiens"]}}