GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE292nnn/GSE292601/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE292601GEOGSEfalseEpithelial interferon-stimulated gene programs modulate chemotherapy sensitivity in colorectal cancer via EPSTI1Precision oncology research typically utilizes patient-derived tumor organoids (PDTO) to predict clinical outcomes, but such efforts are often not directed towards identification of molecular factors underlying differential responses to therapy. Here, we performed bulk RNA-sequencing on treatment-naive PDTOs and combined gene expression data with in vitro drug response data to identify transcriptomic features and programs associated with low chemosensitivity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 sapiens