GEOGenomicsHomo sapiensGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE292718GEOGSEfalseSuper-enhancers-driven SOX4/SMAD3 enhances AXL signaling via membrane phospholipid remodeling to accelerate leukemia progression [CUT&Tag]Cancer often involves aberrant epigenetic activation. In CML-BP, super - enhancer - driven SOX4 and SMAD3 form an auto - regulatory axis. They co - regulate epigenome, activate AXL - related pathways, and mediate membrane phospholipid remodeling. Bemcentinib, an AXL inhibitor, can inhibit CML - BP progression. SOX4/SMAD3 are key factors and Bemcentinib a potential therapy.2026/05/15GSE292718GSM9034441GSM8864151GSM8864141GSM8864152GSM8864150GSM9034440GSM8864148GSM8864149GSM8864146GSM8864147GSM8864144GSM8864145GSM8864153GSM8864142GSM8864154GSM886414334284292718Homo sapiens[41721601]