{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE292nnn/GSE292734/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":[" Mus musculus","Xenopus laevis"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE292734"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration","description":"Why mammals cannot regenerate limbs, unlike amphibians, presents a longstanding puzzle in biology. We show that exposing ex vivo amputated embryonic mouse limbs to subatmospheric oxygen environment, or stabilizing oxygen-sensitive HIF1A enables not only rapid wound healing, but alters cellular mechanics, and reshapes the histone landscape to prime regenerative fates. Conversely, regenerative Xenopus tadpole limbs display low oxygen-sensing capacity, robust wound healing, a regenerative histone landscape, and glycolytic programs even under high oxygen. This reduced oxygen-sensing capacity, in stark contrast to mammals, associates with decreased HIF1A-regulating gene expressions. Our findings thus uncover species-specific oxygen sensing as a unifying mechanism for limb regeneration initiation across vertebrates, reveal how aquatic subatmospheric habitats may enhance regenerative capabilities, and identify targetable barriers to unlock latent limb regenerative programs in adult mammals.","dates":{"publication":"2026/04/09"},"accession":"GSE292734","cross_references":{"GSM":["GSM8864492","GSM8864493","GSM8864490","GSM8864491","GSM8864456","GSM8864457","GSM8864498","GSM8864499","GSM8864496","GSM8864497","GSM8864494","GSM8864495","GSM8864458","GSM8864459","GSM8864460","GSM8864467","GSM8864500","GSM8864501","GSM8864468","GSM8864465","GSM8864466","GSM8864463","GSM8864464","GSM8864461","GSM8864462","GSM8864508","GSM8864509","GSM8864506","GSM8864507","GSM8864504","GSM8864505","GSM8864502","GSM8864469","GSM8864503","GSM8864470","GSM8864471","GSM8864478","GSM8864511","GSM8864479","GSM8864512","GSM8864476","GSM8864510","GSM8864477","GSM8864474","GSM8864475","GSM8864472","GSM8864473","GSM8864481","GSM8864482","GSM8864480","GSM8864489","GSM8864487","GSM8864488","GSM8864485","GSM8864486","GSM8864483","GSM8864484"],"GPL":["34475","34551"],"GSE":["292734"],"taxon":[" Mus musculus","Xenopus laevis"],"PMID":["[41955383]"]}}