{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE292837"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Dlx1&2 Directly Promote Expression of Cxcl14 to Control Synapse Development and Interneuron Survival [ChIP-seq]","description":"Dlx genes have fundamental roles in the generation, differentiation and functions of virtually all forebrain GABAergic neurons. Here we focused on defining the key genes that are dysregulated in Dlx1/2 conditional mutants in mouse immature cortical GABAergic interneurons (CINs), and by identifying DLX-bound putative regulatory elements (pREs) of these Dlx-regulated genes. Within the Dlx-expressing lineage, some DLX-bound pREs were specific to CINs, others appeared to be constitutively bound; the latter class having activity in mature CINs. One such pRE and its associated gene, Cxcl14, is strongly activated by Dlx1/2 and is essential for synaptogenesis onto CINs and for CIN survival.","dates":{"publication":"2026/05/01"},"accession":"GSE292837","cross_references":{"GSM":["GSM8866289","GSM8866288","GSM8866287","GSM8866286","GSM8866295","GSM8866294","GSM8866293","GSM8866292","GSM8866291","GSM8866290"],"GPL":["24247"],"GSE":["292837"],"taxon":["Mus musculus"]}}