{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE292nnn/GSE292838/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE292838"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Dlx1&2 Directly Promote Expression of Cxcl14 to Control Synapse Development and Interneuron Survival [scRNA-seq]","description":"Dlx genes have fundamental roles in the generation, differentiation and functions of virtually all forebrain GABAergic neurons. Here we focused on defining the key genes that are dysregulated in Dlx1/2 conditional mutants in mouse immature cortical GABAergic interneurons (CINs), and by identifying DLX-bound putative regulatory elements (pREs) of these Dlx-regulated genes. Within the Dlx-expressing lineage, some DLX-bound pREs were specific to CINs, others appeared to be constitutively bound; the latter class having activity in mature CINs. One such pRE and its associated gene, Cxcl14, is strongly activated by Dlx1/2 and is essential for synaptogenesis onto CINs and for CIN survival.","dates":{"publication":"2026/05/01"},"accession":"GSE292838","cross_references":{"GSM":["GSM8866301","GSM8866300","GSM8866299","GSM8866298","GSM8866297","GSM8866296"],"GPL":["24247"],"GSE":["292838"],"taxon":["Mus musculus"]}}